"On three separate inspections of Chariot Transportation, Inc. it was discovered drivers without valid Class B California Driver Licenses were driving passenger buses which required a Class B license," CHP Public Information Officer John D. Fransen told TechCrunch.
This idea of a functionally coupled set of genes is not new, and it has been exploited in a number of studies aimed at discovering drivers.
We introduce two generative models of somatic mutations in cancer and study the algorithmic complexity of discovering driver pathways in both models.
Given that driver aberrations recurrently occur around driver cancer genes whereas passenger aberrations randomly exist across chromosomes, finding recurrent chromosomal aberrations is deemed a powerful approach for discovering driver aberrations and associated driver genes.
We investigate the problem of discovering driver pathways, groups of genes containing driver mutations, directly from cancer mutation data and without prior knowledge of pathways or other interactions between genes.
Here, we prove that for both generative models, when mutation data from enough patients is available, the weight function is monotone in the number of discovered driver genes and is maximized by the driver pathway.
These data have been hugely informative in discovering driver mutations that are causally responsible for the development and progression of cancer (Garraway and Lander, 2013, Vogelstein et al., 2013, Wheeler and Wang, 2013).
Indeed, discovering driver mutations is one of the main goals of genome re-sequencing efforts, as the knowledge generated by exome-sequencing will translate from research to the clinic.
The Dubai authorities discover that drivers prefer twenty-five-cent-a-gallon gasoline to the subway.
Empirically, the paper analyses the causes and manifestations of local community initiatives throughout Europe and especially in the Netherlands, to discover the drivers and foci of the initiatives.
