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Consequently, small molecule screens can be designed to discover compounds modifying any of these phenotypes.
A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles.
In order to discover compounds with high fungicidal activity and simple structures, 1,2,3,4-tetrahydroquinoline, a biologically active group of natural products, was introduced to pyrazole structure.
The results in this study provide evidence that an in silico drug discovery strategy coupled with in vitro validation assays can be successfully implemented to discover compounds that may possess therapeutic value for the treatment of diseases and disorders where GDA activity is abnormal.
In the present study we conducted a high-throughput compound screening campaign optimized to discover compounds that interact with a putative ATP-binding domain within IDE.
The NCI COMPARE program was used to discover compounds that preferentially target cells with these phenotypes.
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The substrates of a transporter are not only useful for inferring function of the transporter, but also important to discover compound-compound interaction and to reconstruct metabolic pathway.
The development of these antihistamines dates from about 1937, when French researchers discovered compounds that protected animals against both the lethal effects of histamine and those of anaphylactic shock.
The discovered compounds provide new tools for exploring cannabinoid pharmacology.
Specific information on newly discovered compounds is often difficult to find in chemical databases.
Analysis of the NP chemical space has led to the identification of novel scaffolds [7] and increased chance of discovering compounds possessing novel mechanism of action [8].
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