It discovered a biomarker profile that supports the hypothesis of a circuit including unbalanced oxidative stress, Prolactin cleavage into the anti-angiogenic 16 kDa form and subsequent severe endothelial damage and dysfunction as a major driving force for PPCM.
In this project, we used a novel genetically engineered mouse model (GEMM) of OS to discover a signature plasma miRNA profile that can identify the presence of OS.
However, in addition to enumeration, molecular characterization of CTCs is very interesting to understand their biology and discover an association between gene expression profiles and clinical outcome.
In brief, we discovered a characteristic sound perception profile in WS, associated with structural and functional augmentation of the left AC.
Additionally, from BRCA pathway aberration profile, we discovered a more aggressive subgroup (p <0.05) that was enriched in Her2 positive tumours [ 14] (p <1.4e-5).
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We discovered a correlation between gene expression profiles and glioma prognosis, and we developed a prognosis predictor based on a 58-gene profile [ 5].
In [7], the authors suggest "ProfMiner algorithm" to discover user profile on the basis of preferences and wishes which are user-provided.
In addition, microarray approaches only measure previously identified miRNAs and are not equipped to discover and profile novel miRNAs.
Recently, RNA-seq has been increasingly used to discover and profile the whole transcriptome [ 24].
