They reported similar proportions of immune cell infiltrates (on average, 15% (FNAbx) and 20% (Cbx)) but discordant proportions of malignant epithelial cells (80% (FNAbx) versus 50% (Cbx)) and stromal cells (5% (FNAbx) versus 30% (Cbx)).
Extending this analysis, we examined the proportion discordant copy number calls between the three methods (Table 2).
Comparing PCF and PLA, the proportion of discordant pairs was 14.0% for both treatments, with no differences of discordant pairs (90% CI, −9.0 to 9.0%).
Then, for patients who underwent a postponed ALND after a discordant FS result, the proportion of patients with additional lymph node metastases was analyzed as well as the proportion of these latter patients with an increased TNM N class.
Another study among HIV-discordant couples in Rwanda, in which both members received couples' HIV counseling and testing, found that the proportion of discordant couples using condoms increased from 4%to57%7% after one year of follow-up [ 8].
The proportion in discordant pairs may be much higher.
Comparing NAP and PLA, the proportion of discordant pairs were 12.9 and 18.3%, respectively, with a difference of −5.4%9090% CI, −14.9 to 4.1%).
Comparing PCF and NAP, the proportion of discordant pairs (that is, patients who reported AEs with one but not the other drug and vice versa) were 19.4 and 14.0%, respectively, with a difference of 5.4%9090% CI, −4.4 to 15.2%).
Assuming a 7% threshold as the maximum tolerated difference between PCF and NAP, a 7.9% proportion of discordant pairs, 80% power, and one-tailed test with a 0.05 significance level, the required sample size was estimated to be 100 treated patients.
In this study, we observed a similar proportion of discordant pairs.
