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Generated mapping data file (SAM file) was processed for filtering out discordant paired reads using in-house Perl scripts.
Inserts by discordant reads, total inserts found from discordant paired reads.
The proportion in discordant pairs may be much higher.
Such pairs can be powerful yet far easier to collect than extreme discordant pairs.
Conclusion: Discordant pairs had worse perinatal outcomes within each gestational age category.
In the present article, we survey the new statistics and discuss their applicability to discordant pairs.
Compared with the larger twins, the smaller twins of discordant pairs had higher rates of perinatal mortality.
A practical problem with the design is that extremely discordant pairs that are ostensibly full sibs may be half sibs.
Discordant pairs had lower pair weights at each gestational age and were more likely to include small-for-gestational-age infants.
We conclude that the best statistic(s) for discordant pairs (moderate or extreme) is (are) to be found among the new statistics.
In contrast, discordant pairs and the extreme-proband design provide power for the broadest range of QTL marker-allele freQTL marker-alleles.
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