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Perinatal-level confounders were sex and sex discordance (yes/no), gestational age (<37 or > =37 weeks), birthweight (<2500 g or > =2500 g) and birthweight discordance (<15% discordance, larger or smaller twin of a >15% birthweight discordant pair).
A discordant pair showed mixed exposure between cases and controls.
We, therefore, performed stratified discordant pair analysis based upon the use of a diagnostic scheme.
The point estimates changed somewhat in discordant pair analyses, although the magnitude remained around the same and the change in the direction of the estimates was rather small.
This outcome was consistent across four repeated assays on the discordant pair, even after re- extraction of DNA from the source tissue blocks.
However, using paired-end read mapping and analyzing "discordant pair" evidence could further aid in resolving breseq mutation predictions in or near repetitive genomic regions.
Similar(36)
The proportion in discordant pairs may be much higher.
Our study was designed with 90% power to detect a difference of 6% between discordant pairs, assuming 989 pairs and approximately 20% discordant pairs [13].
Comparing PCF and PLA, the proportion of discordant pairs was 14.0% for both treatments, with no differences of discordant pairs (90% CI, −9.0 to 9.0%).
Such pairs can be powerful yet far easier to collect than extreme discordant pairs.
Conclusion: Discordant pairs had worse perinatal outcomes within each gestational age category.
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