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- (Participant 31, 74 yo White British F, ++) Of the eight participants who thought first about function [ID= 5, 6, 11, 17, 18, 28, 32, 35], six were not discordant (i.e. had a discordance value of 00) and two were discordant.
Probe set 154940-at has a discordance value of five – the largest observed for this dataset.
The minimum organ-to-organ discordance value was 0.95, for stomach versus colon.
Skin, lung, and urinary bladder showed highly independent mutation spectra (maximum discordance value = 1.48 for skin versus brain), in agreement with the presence of specific factors responsible for a large number of the respective tumors (UV light, smoking, aromatic amines).
Of these, seven had less optimistic responses (i.e. were negatively discordant) on either LBP or daily task variants of the TQ and four had less optimistic responses on both (i.e four had a discordance value of – –).
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The distribution of discordance values for the study population was determined.
The majority of probe sets have discordance values of zero (57%) or one (33%).
These percentages were less than the discordance values reported by others [ 44, 53].
Only 18 probe sets have discordance values of four or greater; three of these correspond to differentially spiked transcripts.
The three organs with the smallest sum of discordance values were mammary gland (breast), colon and esophagus.
In addition, a sensitivity analysis is performed to test the robustness of the algorithms used for ranking with respect to changes in concordance and discordance threshold values, which show that the values selected by the model are those providing for a more clear ranking of design alternatives.
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CEO of Professional Science Editing for Scientists @ prosciediting.com