Marked discordance for skewed XCI has been observed in female MZ twin pairs discordant for X-linked gene disorders including Duchenne muscular dystrophy [24], fragile X mental retardation [25] and even complex non-Mendelian disorders such as bipolar disorder [26], [27].
Results: The mean discordance for 346 twins was 11.4% ± 10.5%.
However, a pair of monozygotic twins exhibited discordance for familial hemiplegic migraine.
The purpose of this study was to test nongenetic factors that might explain discordance for dementia in monozygotic twin pairs.
To describe the first case of monozygotic twin sisters with fragile X premutation and discordance for premature ovarian failure (POF).
More important, they offer a logical explanation for the discordance of the two MZ twins with long term discordance for schizophrenia.
This study was undertaken to establish the optimal threshold of birth weight discordance for prediction of adverse outcome in liveborn, nonmalformed preterm twins.
In addition to genetic studies, discordance for BD in monozygotic (MZ) twins (Bertelsen et al. 1977; Sklar et al. 2002; McGuffin et al. 2003; Kieseppa et al. 2004) invites speculation about environmental risk factors.
131I-MIBG and 111In-pentetreotide tumor uptake pattern concordance (or discordance) for each subject is given in the first column of Table 2. Table 3 provides a summary of individual lesion MIBG and pentetreotide uptake status for these six subjects.
We have been able to establish genome-wide (CNVs and SNPs) discordance for MZ twin pairs.
Data were also corroborated by quantitative real time RT-PCR, showing discordance for only one transcript, i.e. ZFP36L1.
