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The second type of discordance, concerning the monophyly of subsections, suggests that introgressive hybridization has occurred inside the CCCP clade, with at least two evidenced instances.
No discordance concerning BRAF mutational status was observed among the 46 patients with at least two distinct melanoma samples, and the median BRAF-M% variation was 2.5%%.
The literature demonstrates that medical residents and practicing physicians have an attitudinal-behavioral discordance concerning their positive attitudes towards clinical practice guidelines (CPG), and the implementation of these guidelines into clinical practice patterns.
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The second type of discordance concerns the monophyly of subsections: Chlamydodorae and Platyphyllae are paraphyletic in the chloroplast phylogeny (at least for F. craterostoma and F. trichopoda), and monophyletic in the nuclear phylogeny.
Indeed although discordances exist concerning the risk to develop malaria in the presence of helminth coinfection [41], [42], [43], a recent study showed that the presence of helminth infection modulates the immune response to malaria parasites, and could interfere with gene expression [44].
Discordances concern both terminal nodes of the phylogenetic trees and one deep node defining relationships between subsections.
We found one case of discordance with relatives concerning the WD decision.
Finally, there has been some discordance in reports concerning expression of various tumor markers in paired primary and metastatic disease.
These data clearly provided valuable data concerning the discordance between molecular and clinical risk assessment (n=27; discordance rate: 37%).
With respect to the first two factors, main discordance affected the endocrine treatment, consistently with the reported uncertainty concerning the optimal treatment strategy (Goel et al, 2009).
In summary, the main challenging issue concerning clinical management of EC patients is underscored by the discordance between the preoperative risk classification of the tumour and the final surgical pathology.
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