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Concordance and discordance between methods were evaluated by pairwise comparison of CNs (Table 1).
The reasons for discordance between methods for ER and HER2 arise as a result of the different thresholds used for positivity since the cutpoint at which the automated score was dichotomised was not optimised against the manual dichotomous score.
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Accordingly, we aimed (1) to describe the implementation of each method; (2) to assess the extent of discordance between the methods by comparing the probabilities that particular medicines would be reported by each method; (3) to explore the correlations between medicines exposure at unit and individual levels.
Plasma PCR COBAS AMPLICOR CMV MONITOR) and pp65Ag assays were effective in detecting CMV infection, however, discordance between both methods were frequently observed.
Discordance between the methods was found in 32 (35%) paired samples, which were negative by MFC-MRD, but positive by ASO RQ-PCR.
The discordance between different methods has been attributed to the types of services studied, the recall period, socio-demographic profile of the target population, poor health status and symptoms, high stress or high treatment needs, errors in administrative records, incorrect recording of records and patients misspecification of a treatment or service [ 2, 5].
Only age was associated with the discordance between the two methods (p = 0.047) with older patients in the discordant group.
The purpose of this study was to evaluate discordance between different audit methods in pancreatoduodenectomy a common major surgical procedure.
There was discordance between the two methods in eight cases.
The greatest discordance between the two methods occurs among breast tumors that receive an indeterminate IHC score of 2+.
In those set in African countries, considerable discordance between these two methods of exposure measurement was observed [ 48– 51].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com