Meanwhile, five professors from the Massachusetts Insti tute of Technology presented to Congress and the White House a petition calling on the United States to discontinue the development of high‐accuracy MIRV warheads capable of at tacking enemy missiles.
AstraZeneca has discontinued the development of its experimental diabetes drug, Galida, doing more damage to its already-weakened pipeline and casting a cloud over a new class of medicines that doctors hoped would control blood sugar and reduce the risk of heart disease.
Open-label metformin was also continued in participants initially randomized to receive metformin (850 mg twice daily as tolerated) during the DPPOS, unless discontinued for the development of diabetes requiring management outside of the protocol, or for reasons of safety and/or tolerability.
Phenformin and tolbutamide were discontinued because of the development of lactic acidosis and an excess of CV mortality, respectively.
The treatment was eventually discontinued due to the development of lower abdominal subcutaneous metastases and progressive disease after the 14th vaccination.
He had been started on HAART several months prior to this presentation, which was discontinued due to the development of a rash.
These issues included: (1) which patients should be considered candidates for the initiation of ERT, (2) treatment goals, (3) assessing response to ERT, (4) when to discontinue ERT, (5) the development of guidelines about ERT in severe Hunter syndrome, and (6) the role of government and health reimbursement agencies in the determination of eligibility for ERT in severe Hunter syndrome.
Despite having a partial response on CT imaging, paclitaxel was discontinued due to the development of grade 2 peripheral neuropathy She received 2 weeks of single agent carboplatin (AUC2) but developed dose limiting thrombocytopenia (79 × 10/L) resulting in two weeks dose delay.
Reasons for discontinuing the intervention included the development of knee pain (one), anticipation of a scheduled operation (one), partner sickness (one), and no explanation (one).
It is often difficult to discontinue benzodiazepines because of the development of dependence.
