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The biological activity of bupropion can be attributed to a significant degree to its active metabolites, in particular to S,S-hydroxybupropion. GlaxoSmithKline developed this metabolite as a separate drug called radafaxine, but discontinued development in 2006 due to "an unfavourable risk/benefit assessment".
INSPIRE PHARMACEUTICALS, Durham, N.C., discontinued development of a treatment for chronic bronchitis.
And last year Roche discontinued development of a heart drug after it failed to work in a late-stage clinical trial.
Despite later basing some Windows NT and Windows 95 developments on code written for IBM and OS/2, Microsoft soon discontinued development of further interface features for OS/2.
Roche, the Swiss pharmaceutical giant, has discontinued development of a potentially important diabetes drug, a move that could raise safety questions about the entire category of drugs, which includes the controversial medicine Avandia.
With the discontinued development of MAb 9F3, 13H5, ACO-1 and Rontalizumab100, two anti-IFN-α monoclonal antibodies (mAbs), Sifalimumab (MEDI-545) and AGS-009, have achieved a safe and dose-dependent reduction of the IFN-α signature in their clinical trials for SLE treatment101,102,103. Sifalimumab is a fully human mAb in phase II clinical trials for the treatment of SLE.
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The company, based in Salt Lake City, said it would discontinue development of the drug.
In December 2006, the trial revealed that torcetrapib raised patients' risk of death by 60percentt, forcing Pfizer to discontinue development of the drug.
These small, up-front commitments position them to ramp up or discontinue development of the technology as its performance becomes clearer.
An historic name in software will effectively pass into history in February as AOL discontinues development and active support for the Netscape browser, according to an official blog.
Twitter, which bought the TweetDeck app in 2011, recently announced it was discontinuing development of the iOS, Android and Adobe AIR versions of the software.
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