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Estimates of EFS may be biased by early treatment discontinuations without an EFS event.
Patients without measurable disease, clinical progression, or study discontinuations without radiology documentation at the end of the study were considered non-evaluable for response.
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The slide show also excludes cars that are headed for discontinuation without replacement, such as the unlamented Chevrolet Astro van.
Additionally, one placebo-arm participant had evidence for tubulopathy after drug discontinuation without subsequent follow-up.
Additionally, this dose was associated with minimal side effects upon discontinuation without a taper.
This workflow can be easily integrated into clinical studies, because it enables several points of discontinuation without loss of information.
Third-line treatment was defined in the same way as any addition or discontinuation without a break in treatment.
Successful discontinuation is defined as discontinuation without relapse of symptoms and without occurrence of withdrawal effects that make it necessary to restart medication.
The HONOR (Humira discontinuation without functional and radiographic damage progressioN follOwing sustained Remission) study was conducted to elucidate clinical, functional and radiographic outcomes after discontinuation of adalimumab (ADA).
In order to accurately distinguish gaps of varying length in drug treatment for chronic conditions from discontinuation without resuming therapy, short-term observation does not suffice.
Given a high rate of antidepressant discontinuation without consulting their physicians, closer communication between patients and their physicians should be encouraged.
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