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Consensus has not been reached over the time window of preoperative sorafenib neoadjuvant treatment for RCC, the discontinuation time of the drug, and the time of performing the operation.
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Probability of vasopressors discontinuation over time was similar in the two groups (Figure, p for logrank test = 0.67).
Rates of discontinuation and time to discontinuation were compared between LY2140023 and placebo.
Interestingly, in this study, we were able to evaluate the different reasons for discontinuation over time.
Persistence was analysed using Cox regression analysis, which models the risk of treatment discontinuation over time.
Enrollment (treatment) errors, reasons for study discontinuation and time of withdrawal from the study will be described.
Additional factors such as lack of efficacy and poor adherence may also contribute to DMARD discontinuation over time during biologic treatment [ 12].
Further, the model assumed the rate of hospitalisation as a proxy for relapse rates and did not account for the naturalistic fluctuations in relapse and treatment discontinuation over time.
First, she had clear response predictors (i.e., euphoric mood, absence of substance abuse, non-rapid cycling) with evidence of drug discontinuation three times with depressive episode recurrence, and, more notably, re-responsive illness with lithium reintroduction.
Differences in patient discontinuations over time represent a further limitation.
After controlling for key covariates (Table 2), blacks taking sulfonylurea medications had a rate of discontinuation 1.8 times higher than whites (95% CI: 1.2, 2.7).
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