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An electronic questionnaire examined local protocols for PTH, triggers for commencing and discontinuation, target temperature ranges, use of muscle relaxants, cooling equipment, monitoring and complications.
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Assuming that 5% of patients would be excluded from the efficacy analysis owing to study discontinuation, the target total sample size of 300 patients provided >90% power to detect a difference between groups 2 and 3 and group 1 in ACR20 response rates at week 14 (α=0.05).
Assuming a 25% discontinuation rate, the target enrollment was 8,000.
Finally, method switching and discontinuation should be targeted in longitudinal studies.
The first type of studies targeted discontinuation of specific medicines, whereas the second type examined sensible discontinuation of an array of medicines guided by medication reviews.
Greater awareness of the time course of the evolving pathophysiology of the underlying disease process and improved diagnostics and genetic profiles of vulnerability will lead to better selection of treatment type and intensity, improved timing of administration and discontinuation, and more sharply targeted therapies.
By not pursuing a higher adequacy target, the early discontinuation of incident PD patients observed occasionally can be avoided.
Tapering of sirolimus and MMF began after day 100 post-HCT with the target day of discontinuation of each drug by 6 months post-HCT.
† Defined as a stop of treatment triggered by the physician despite guidelines recommending a continuation of the therapy (e.g. discontinuation of statin therapy after reaching target values for LDL-cholesterol which then rose above target again).
However, after the discontinuation of EOX therapy, erbB2 targeted therapy with trastuzumab monotherapy was unable to provide substantial disease control, since his general health condition deteriorated rapidly.
The binary outcome targets were firstly discontinuation (versus completion) and secondly non-publication (versus publication); we used primary publication (in a peer reviewed journal) for this modelling process.
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