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Guided discontinuation strategy is a less intrusive intervention, but may lead to more relapses.
This article reviewed the main studies designed to evaluate the concept of maintenance therapy after induction chemotherapy and discontinuation strategy.
In the current economic evaluation, costs and health outcomes of discontinuation strategy will be compared with the results of maintenance treatment in patients with remitted first episode psychosis.
Pooled analysis showed a PCT-guided antibiotic discontinuation strategy had fewer total days with antibiotics (MD − 1.66 days; 95% CI − 2.36 to − 0.96 days), longer antibiotic-free days (MD 2.26 days; 95% CI 1.40 3.12 days), and lower short-term mortality (RR 0.87; 95% CI 0.76 0.98), without adversely affecting other outcomes.
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These studies used PCT in three clinical strategies: initiation, discontinuation, or combination of antibiotic initiation and discontinuation strategies.
However, one major limitation of these meta-analyses was unexplainable significant heterogeneity among included trials, possibly due to the fact that the different PCT guidance strategies (including antibiotic initiation, discontinuation, or combination of antibiotic initiation and discontinuation strategies) had been evaluated in these trials.
A systematic review of catheter discontinuation strategies for hospitalized patients reported that the intervention of a "stop order" to facilitate prompt removal of unnecessary catheters reduced the duration of catheter use by 1.06 days, and use of either catheter reminders or stop orders decreased the CA-UTI rate by 53% [ 60].
In the Alternative strategy, discontinuation of second-line ART occurred upon detection of antiretroviral failure, specified by WHO guidelines.
They describe the complex, evolving relationship between ageing and MS pathophysiology, highlight the lack of evidence for the safety and efficacy of disease-modifying therapies in elderly patients, and discuss treatment discontinuation and wellness strategies.
Regardless of group differences, however, high-dose BZD users are believed to suffer more frequently from comorbid mental disorders, might not sustainably benefit from current discontinuation and withdrawal strategies, and are thus exposed to an increased risk of impairment and injury [ 13- 16].
Understanding patient-reported reasons for discontinuation can influence intervention strategies to improve long-term adherence to EBCMs.
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