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We used the term physician-specific discontinuation risk for this phenomenon.
Being in the Part D gap period increased discontinuation risk: HR = 1.09 (95 % CI: 1.03, 1.16).
Low-income subsidy status decreased discontinuation risk: HR = 0.77 (95 % CI 0.69, 0.86).
Higher physician preference, estimated using their prescribing habits, was associated with decreased discontinuation risk in patients with RA treated with TNF antagonists.
In this paper, we use the term 'preference' to describe the first phenomenon (physician's favourite drug) and 'physician-specific discontinuation risk' to describe the second.
Between-physician differences in response to the same clinical situation (physician-specific discontinuation risk) have previously been studied in patients with RA treated by TNF antagonists.
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This assessed discontinuation risks in a mixed group of patients, but having only 20% of the cohort without diagnosed CVD and following up patients for only 1 year.
In addition to adopting a fixed follow-up time, these methods included: 1) matching patients based on a propensity score [ 15] of extensive scope and detail [ 16], and 2) deriving intent-to-treat and post-discontinuation risk estimates [ 17].
Relative to NNRTI-based regimens, PI-based regimens demonstrated a greater risk of discontinuation (hazard ratio [HR], 1.32; p <0.001).
91, 94 Similar to the findings on medication discontinuation, the risk for hospitalization was lowest for olanzapine-treated patients and highest among the quetiapine-treated patients.
Medications possibly associated with medication discontinuation or risk of fractures included anticonvulsants, antidepressants, antipsychotics, antihypertensives, lipid-lowering drugs, non-steroidal anti-inflammatory drugs, steroids, proton pump inhibitors, H2-receptor blockers, hormone replacement therapy, thiazolidinediones, and aromatase inhibitors.
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