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Our objective was to analyse the characteristics of LCP patients, including frequency for and reasons of LCP discontinuation, quality of life, and survival times of discontinued LCP patients.
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No published studies to date, however, have specifically examined the impact of HRT discontinuation on quality of life.
To our knowledge, no studies to date have specifically examined the impact of HRT discontinuation on quality of life.
The availability of longitudinal survey data for HRT continuers and discontinuers provides an important opportunity to examine the impact of HRT discontinuation on the quality of life of elderly women.
Paclitaxel-induced neurotoxicity remains a prominent complication of treatment, resulting in early treatment discontinuation and impacts on quality of life.
Although multiple studies report on significant associations between a few predictors (e.g. age, oocytes retrieval, embryo fertilization, transfers and quality) and discontinuation that consistently show the same direction of association, these represent less than half of the studies investigating each particular predictor.
One good-quality randomized discontinuation trial evaluated children with a polyarticular, pauciarticular, or systemic JRA [ 9].
One fair-quality randomized discontinuation trial of 43 subjects with JIA evaluated tocilizumab [ 15].
One good-quality randomized discontinuation trial compared adalimumab to conventional therapy among children with polyarticular JRA [ 7].
One good-quality randomized discontinuation study evaluated abatacept in children with persistent oligoarthritis, extended oligoarthritis, polyarthritis, or systemic JIA [ 6].
One poor-quality randomized discontinuation trial compared anakinra to conventional therapy among children with polyarticular, pauciarticular, or systemic JIA [ 8].
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