Exact(10)
This study evaluated the pharmacokinetics (PK), pharmacodynamics (PD), and safety of continuous clevidipine infusion, including the potential for tolerance during treatment and for rebound hypertension upon discontinuation, over 72 h in subjects with mild to moderate essential hypertension.
Probability of vasopressors discontinuation over time was similar in the two groups (Figure, p for logrank test = 0.67).
Interestingly, in this study, we were able to evaluate the different reasons for discontinuation over time.
Figure 1 shows the number of AEs resulting in discontinuation over the study periods.
Persistence was analysed using Cox regression analysis, which models the risk of treatment discontinuation over time.
Additional factors such as lack of efficacy and poor adherence may also contribute to DMARD discontinuation over time during biologic treatment [ 12].
Similar(50)
Differences in patient discontinuations over time represent a further limitation.
Treatment with OLAI resulted in fewer relapses and treatment discontinuations over the 5-year time horizon.
The diminished infliximab efficacy observed during the 3-year OLE is related to the high rate of patient discontinuation, because over half of the patients entering the OLE discontinued by week 204 and response rates were calculated using an intent-to-treat approach.
I've lived through a great deal of camera discontinuation announcements over the past decade, but none were as eerie to me as this one.
It may represent either increasing discontinuation rates over time, perhaps because of adverse events with active therapy, or patients who had previously achieved a response at a given level now experiencing a decrease in their magnitude of improvement to below the level in question, or some combination of these.
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