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Median time from cART initiation to first prolonged stock-out-related discontinuation or modification was 9 months (IQR, 5 13).
The variable could have one of five values: (i) no cART discontinuation or modification (reference group); (ii) cART regimen modification due to stock-out; (iii) cART regimen modification not due to stock-out; (iv) cART discontinuation due to stock-out; and (v) cART discontinuation not due to stock-out.
If needed, discontinuation or modification of the treatment may be considered at the discretion of the physician.
hThese include all SAEs, selected AEs, AEs of special interest, and AEs/SAEs that lead to treatment discontinuation or modification.
However, mould-active prophylaxis was also associated with a significantly increased risk of adverse events requiring discontinuation or modification of therapy and did not affect overall mortality.
A recent study examined factors associated with ARV discontinuation or modification and found women had a higher hazard for short-term toxicity [ 55].
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As a reminder, all communication regarding the discontinuation or modifications of these services to your customers is your responsibility.
Prolonged discontinuations related to drug stock-outs were independently associated with a higher risk of interruption in care or death compared to no discontinuations or modifications.
As shown in Table 3, stock-out-related discontinuations were independently associated with a higher risk of interruption in care or death compared to no discontinuations or modifications (adjusted hazard ratio [HR], 2.83; 95% CI, 1.25 6.44).
Because of the poor number of AEs causing the discontinuation or the modification of therapy, data regarding the comparison of their proportion between the different treatments were not shown in the previous Table.
No differences were found in the proportion of AEs between lamotrigine and CBZ (p = 0.311), but a tendency in a higher number of AEs causing the discontinuation or the modification of therapy was seen for CBZ (p = 0.06).
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