He said the discontinuation of Flurizan development would allow investors to focus on the company's fast-growing genetic testing business.
Although armodafinil was generally well tolerated in this and prior phase 3 studies, the lack of statistically significant efficacy on the primary outcome in two of three studies has led to the discontinuation of the development program for adjunctive armodafinil in bipolar I depression.
However, accrual was terminated on 7 April 2012, after completion of three dose levels (DLs), due to discontinuation of RO4929097 development.
However, American College of Rheumatology 50%ACR5050) improved benefits were less impressive, which probably led to the discontinuation of clinical development activities [ 5].
In August 2006, Cephalon announced discontinuation of modafinil development for ADHD due to safety concerns raised by the FDA, and the company intends to replace modafinil by its successor compound in development, armodafinil [ 61].
Only six respondents (4%) were aware of a negative or inconclusive study for which publication was not planned, in three cases this was due to the discontinuation of product development.
Stable disease is recognised as a significant endpoint in the evaluation of clinical benefit associated with many targeted agents, and a focus on only conventional complete or partial responses assessed in the conventional manner using RECIST[ 41 ] may underestimate efficacy and risk discontinuation of the development of active new agents[ 42 ].
If the putative animal model doesn't only exhibits characteristics of the neurobehavioral disorder to be modeled, but also abnormalities that are not symptomatic, then it needs to be viewed critically [ 185] and one may even consider discontinuation of further development.
Despite the discontinuation of internal game development at 3D Realms, development of the game did not cease entirely.
The most common causes of study discontinuation were development of exclusion criteria (3.8%) and protocol violations (2.9%).
