Patients with a recently implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless clopidogrel is discontinued beforehand, but clopidogrel discontinuation has been associated with a high rate of adverse events due to stent thrombosis.
Finally, when discontinuation does occur, there may be value to gradually discontinuing lithium when appropriate, given that gradual discontinuation has been observed to substantially reduce the risk of mood episode relapse [ 56, 57].
One patient received 12 cycles, discontinued the study for an unrelated medical condition and, at the time of discontinuation, had an increase in tumour size not yet reaching disease progression.
The drive is particularly intense at Oldsmobile, where G.M., in advance of the division's looming discontinuation, has offered rebates of up to $3,000 a vehicle, plus a five-year, 60,000-mile warranty.
Peripheral lymphocyte reconstitution following drug discontinuation has been considered relatively rapid (2 4 weeks), based on short-term studies.
Triptan discontinuation has been associated with concomitant narcotic use, medication overuse, and higher Migraine Disability Assessment Test or Beck Depression Inventory scores[25, 22].
Well-designed, long-term studies of discontinuation have not been conducted; such evidence is needed to provide a scientific basis for practice guidelines.
All enrolled women (regardless of gel group) were asked to provide written consent to continue in the trial after the discontinuation had been explained.
Additionally, pain resulting from remifentanil discontinuation has been reported [ 29].
The reason, time and date of discontinuation had to be recorded in the eCRF.
