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No serious adverse events were reported during Duotrav therapy but adverse events in six patients led to treatment discontinuation either at the patient's request or at the doctor's discretion, clearly suggesting that individual patients should be closely monitored.
It is unclear, however, whether these or other factors are the main predictors of DMARD discontinuation in early RA, or whether different factors predict discontinuation either due to lack of efficacy or to adverse events [ 11].
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Withdrawal symptoms are linked to discontinuation of either opioids or benzodiazepines and result from central nervous system irritability, gastrointestinal dysfunction, and autonomic nervous system dysfunction.
Outcomes after discontinuation were either 'sustained response' or 'virological relapse'.
The effects on bleeding time persist for about 1 week after discontinuation of either drug.
A1C and body weight rose to pretreatment values 12 weeks after discontinuation of either exenatide or insulin glargine therapy.
For the infliximab [ 14] and tocilizumab trials [ 32], the reasons for discontinuation were either absent or not clearly stated.
All TEAEs were graded as mild or moderate, and none led to study discontinuation during either study phase.
The most common reasons for discontinuation were either switching to another route or formulation (53.6%) or improvement, resolution, or cure of the infection (43.6%).
Gastrointestinal-related adverse events rarely led to early discontinuation of either therapy, however, as only one tigecycline patient stopped treatment early due to nausea, as did two imipenem/cilastatin-treated patients secondary to diarrhea.
In the event of temporary discontinuation for either of these reasons, measure 25OHD on stored serum from blood sample collected at the time of the elevated calcium or calcium to creatinine ratio if not a routine 25OHD measurement time.
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