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It has been suggested that the considerable beneficial effect of lithium found in these studies was due to such a discontinuation effect (Moncrieff [1997]).
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Modafinil and mirtazapine were well tolerated, producing minimal positive subjective effects and no discontinuation effects in this open-label study.
However, further research is needed to test eszopiclone's discontinuation effects (Roth et al 2005).
An attempt was made to reduce these possible effects in the present study by suggesting to the investigators that they downtitrate the doses of the previous antidepressants to the lowest dose in the last week to reduce potential discontinuation effects in patients entering the study.
Patients were excluded if their medication possession ratio (number of days drug supplied divided by the number of days in the follow-up period) was <80% or clopidogrel or aspirin was not prescribed within 30 days before an end point to reduce bias from poor drug adherence or antiplatelet-discontinuation effects.
The most important consequence would be that the relatively minor side effects would reduce adherence or lead to discontinuation, an effect that is indirectly included in our model (via reduced compliance).
No patient experienced discontinuation side effects or re-emergence of psychosis during the 4-week taper.
24 Citalopram was chosen for its once a day dosing, lack of discontinuation side-effects and low potential for drug-drug interaction, all attractive characteristics in LLD.
The most common reasons for discontinuation are the effect of the treatment being too weak, the side-effects too great or the market for the treatment too small.
The tolerability of treatment will be defined as side effect discontinuation, as defined by the proportion of patients who discontinued treatment due to adverse events during the trial.
We could not find any differences between the pooled groups in side effects and discontinuation due to side effects.
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