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Seventeen (25.4%) patients underwent dose adjustment or Myfortic discontinuation during the study period.
Our aim was to estimate the duration of HT use and analyze factors associated with its discontinuation during the period before the publication of articles challenging the safety of HT.
Additionally, we used the Kaplan-Meier method to determine the rates of change in AAD use and discontinuation during the year after AAD initiation.
The first 30-day BARC bleeding episodes were associated with an increased rate of subsequent premature DAPT discontinuation during one-year follow-up (4.7%% vs 11.4 %; odds ratio: 2.60; 95%% confidence interval: 1.04 to 6.50; p= 0.035).
Before its discontinuation during World War II, the NHL played a full 10-minute overtime period.
Our findings of discontinuation during this period appear inconsistent with the guidelines.
Similar(27)
Adverse events in the insulin cohort were an infrequent reason for discontinuing therapy (2.8%, 6.7%, and 2.9% of discontinuations during each period, respectively).
Stock-out-related discontinuations continued to be independently associated with interruption in care or death (adjusted HR, 3.09; 95% CI, 1.36 7.05) when we assumed that all treatment prolonged discontinuations during drug shortage periods, as reported by the pharmacy, were due to drug stock-outs, regardless of the explanation in the patient's medical record (Table 3).
Table 3 outlines the treatment-emergent AEs and discontinuations during the study.
Most TEAEs resulting in discontinuations during the dose-optimization phase were judged to be related to study drug and most were moderate in severity and resolved after discontinuation.
By contrast, inadequate response became a more common reason for discontinuing therapy as the study progressed (21.0%, 33.8%, and 54.5% of discontinuations during each time period, respectively).
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