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Furthermore, new cells proliferation discontinuation caused by N-depletion leads to termination of structural lipid biosynthesis.
Fewer responses were reported, in part due to early treatment discontinuation caused by adverse events.
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Premature discontinuation causes loss of information, potentially resulting in attrition bias leading to problems during interpretation of trial findings.
The overall incidences of adverse events, serious adverse events, and discontinuations caused by adverse events were similar among the groups (Table 1).
There were fewer discontinuations caused by adverse events in the ATV plus SQV groups (9% and 11%, respectively) than in the RTV plus SQV group (30%).
In all, 13 discontinuations caused by AEs (four in the bimatoprost/timolol PF group and nine in the bimatoprost/timolol group) were reported, with the majority being ocular AEs (see online supplementary figure S1).
All discontinuation causes were ascertained by electronic and clinical reports (see Table 1 for categories besides the adverse event definition).
For maximum impact, interventions to reduce burden should be directed at discontinuation causes that are common across treatment stages and/or are stage unique but endorsed by many people.
We empirically determined a regime in which seven days of PTZ treatment and seven days of subsequent PTZ discontinuation respectively cause a decrease and an increase in climbing speed of Drosophila adults.
Relevance was also assessed by comparing the proportion of the side effects that caused discontinuation of initial antidepressant use, including the categories "discontinuation" and "switching to other treatment".
The most common side effect that caused discontinuation within 1 year was irregular bleeding.
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