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The hydraulically coupled model gives higher CSO volume than the fully disconnected model for the potential infiltration scenario, whereas no difference is seen between these two models in the realistic infiltration scenario.
(since in the disconnected model, F families allow the estimation of F contrasts and in the connected model K − 1 independent effects are estimated).
For QTL mapping, an additive genetic model was chosen and the joint analysis across families was performed with a model assuming specific QTL effects for every family (disconnected model) [ 26] as described in detail by Steinhoff et al. [ 9].
Local differences in access to specialist antenatal care, as found in this study in which the women had been given care in four different settings, seem to explain the negative consequences of the disconnected model of care.
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Disconnected models are mostly fancy organizers.
Disconnected models, including the vast majority of PDAs, get their data fixes mostly via cables hooked up to parent computers.
In the reference design, there is no distinction between connected and disconnected models because although the reference allele can be modelled as consistent ('connected') across families, the effect of the other founder allele in each family is unique and cannot be tested for variation across families.
The optimal IBD linkage model for multiple family analysis appears to vary among studies and traits; disconnected models are superior when QTL allele effects vary considerably across families, possibly due to epistatic interactions with the family genetic background (Blanc et al., 2006; Coles et al., 2010; Steinhoff et al., 2011, 2012).
Music plays a big part in the glossy world of Glamorama too, whose disconnected male-model lead, Victor, spends his nights spotting the major pop stars of the mid-90s (including, memorably "the two Aphex Twins") and yawns out Green Day lyrics rather than actually form sentences of his own.
One sure thing: if he really wants to go against big corporations and finance, to shield it from pressure, Omidyar should keep its business model disconnected from its editorial operation.
The need to have a quantitative estimate of the uncertainty of prediction for QSAR models is steadily increasing, in part because such predictions are being widely distributed as tabulated values disconnected from the models used to generate them.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com