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The company, based in London, has been accused of misleading doctors and patients by playing up favorable research and not adequately disclosing studies that show Seroquel increases the risk of diabetes.
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Disclosing study documents, in particular the study protocol and financial agreements, was found to be most problematic with only 31% of respondents willing to disclose these publicly.
However, disclosing study documents, in particular the study protocol and financial agreements, was found to be most problematic with only 31% of respondents willing to disclose these publicly.
Each of these forms of stigma were seen as an incentive to avoid being seen taking the study medication, or disclosing study participation.
Whatever the drug's fate, the episode is likely to fuel efforts by some medical experts, including Dr. Nissen, to persuade lawmakers to require makers of drugs and medical devices to disclose study results publicly.
But even before the recent Avandia episode, advocates for greater study transparency like Dr. Nissen were pushing lawmakers to take the next step by requiring that producers of drugs and makers of devices not only register trials but also publicly disclose study findings.
Agreement to disclose study details was very high for most individual items (Additional file 1).
Association between willingness to disclose study details and study phase was assessed using the chi-squared test for trend.
However, academic research is also competitive nowadays and researchers might therefore also be reluctant to disclose study details.
Nevertheless, we found no association between characteristics associated with non-response and the willingness to disclose study details.
Authors submitting articles to these journals must disclose all relationships that might involve the appearance of a conflict of interest, and they must disclose study funding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com