An increase in TAR disclosed a disease progression in this patient, which was confirmed by the consecutive disease course.
We describe an Italian patient affected by sporadic ALS with the SOD1 G93D mutation that disclosed an unusual rapid progression with death occurring after 30 months from the symptom onset.
In the past few years, the role of long noncoding RNAs (lncRNAs) in tumor development and progression has been disclosed although their mechanisms of action remain to be elucidated.
The first evidence that disclosed the possibility of arresting tumor progression by means of inhibitors of the uPA activity was achieved with anti-uPA antibodies [ 14, 15].
In this study, we disclosed that β-arrestin1 is critically involved in CML progression.
However, recent advances have disclosed the significance of epigenetic events in the development and progression of human tumorigenesis.
This chapter provides examples of clinical trials that use the endpoint, time to progression, and discloses the advantages (and disadvantages) of using this particular parameter as an endpoint in oncology clinical trials.
IF and IEM analysis disclosed the dynamic localization of the KIFC1-like protein and microtubules along the progression of spermatogenesis.
Univariate statistical analysis further disclosed that low levels of either Cyr61 or CTGF were related with the progression of NSCLC, and the downregulation of Cyr61 and CTGF was more notable in patients with family history than those without family history.
This study disclosed the prognostic value of MALAT1, an important lncRNA involved in cancer metastasis and progression.
