The monotonically increasing accommodation of subsequently generated action potentials during a train of class P3 AC cells resulted in an intermediate average discharged frequency of 85.1 ± 3.9 Hz (34 cells), significantly lower than in class P1 FS cells (P < 0.01) but higher than the frequency observed in class P2 STUT cells (P < 0.05; Fig. 4C).
Rapid cooling causes transient increases in discharge frequency, whereas rapid warming produces transient discharge inhibition.
If the cooler temperature is maintained, the discharge frequency adapts to a frequency of static discharge that is directly related to the cooler temperature.
In fact, mechanoreceptor nerve fibres that are sensitive to cold have increased spontaneous discharge frequency in the presence of cold stimuli.
When the receptor is rapidly cooled, its discharge frequency rises steeply and then declines gradually to a lower constant level; on rapid warming, the opposite response occurs.
Warm receptors respond in a similar fashion to that of cold receptors, except that they show a dynamic response of increased discharge frequency to warming and a transient inhibition of discharge to cooling.
When the cold receptor is warmed again, a transient decrease, or inhibition, in discharge frequency occurs, after which the frequency rises again and finally adapts to a new static value.
Cold receptors respond to sudden cooling with a transient increase in discharge frequency (called the dynamic response) that is directly related to the prior temperature and the magnitude and rate of the temperature decrease.
The results indicate that discharge frequency has a negligible influence on the conversion of CO2 at a constant discharge power.
Increasing pulse-off time decreases the effective discharge frequency and hence decreases the discharge energy across the electrodes resulting in low machining rate.
Furthermore, CGRP may modulate central sensitization by increasing the discharge frequency of wide dynamic range neurons in the spinal cord, thus modulating nociceptive transmission [27].
