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The neuromuscular junction is uniquely designed to produce tight coupling of nerve and muscle action potentials at discharge frequencies ranging from 1 50 Hz for extended periods of activity.
The uniformity of very high frequency (VHF) plasma produced with the ladder shaped electrode was examined by changing VHF power feeding positions for different discharge frequencies.
As shown in Figure 4, EEG in m−/p+ mice showed a pattern beginning with sudden isolated giant spike-wave discharges with no behavioral accompaniment, but then progressed to higher spike discharge frequencies, at which point the mice displayed sustained behavioral arrest and subtle myoclonic movements.
The discharge frequencies measured were the peak instantaneous, static hold phase, and Linit static discharge frequencies.
Maximal discharge frequencies, determined from a frequency current relationship and discharge frequencies at current injections of 700 pA (1 s) are given.
Discharge frequencies were determined as the reciprocal of the inter-spike intervals (ISIs).
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Rapid cooling causes transient increases in discharge frequency, whereas rapid warming produces transient discharge inhibition.
If the cooler temperature is maintained, the discharge frequency adapts to a frequency of static discharge that is directly related to the cooler temperature.
In fact, mechanoreceptor nerve fibres that are sensitive to cold have increased spontaneous discharge frequency in the presence of cold stimuli.
When the receptor is rapidly cooled, its discharge frequency rises steeply and then declines gradually to a lower constant level; on rapid warming, the opposite response occurs.
Warm receptors respond in a similar fashion to that of cold receptors, except that they show a dynamic response of increased discharge frequency to warming and a transient inhibition of discharge to cooling.
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