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Given that roulette wheels no longer had discernible defects, he realized he would need to develop a new strategy.
We reasoned, given our earlier observation that Vav1+/−/Vav2−/−/Vav3−/− mice (which express only Vav1 but not Vav2 or Vav3) show no discernible defects in T-lineage cells [29], that reintroduction of Vav1 alone should be sufficient to rescue VavNULL T cell development and function.
Current questions about lead exposure focus on the consequences of levels too low to have erupted into blatantly discernible defects.
In the absence of any discernible defects on hair cell integrity and prompted by the in vitro results, we then analyzed spiral ganglion density and synaptic connections.
Homozygous PSD95SH3W470L mice were fertile, showed normal Mendelian transmission, no obvious seizures, tremor, ataxia or other overt neurological abnormality, nor any discernible defects in gross neuroanatomy as determined histologically (data not shown).
lrrk NS flies did not show any discernible defects in dopaminergic neuron number or morphology with age (supplementary material Fig. S1), which is consistent with what has previously been reported for lrrke03680 flies (Wang et al., 2008).
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The two-month investigation by the safety agency concluded that "no discernible defect trend exists" and modifications that G.M. already has agreed to make are sufficient to reduce the potential for a fire.
At the completion of its investigation NHTSA concluded that no discernible defect trend exists.
In contrast, mice deficient in LMAN1 do not display any discernible defect in the hepatic intracellular levels of cathepsins Z and C, or plasma levels of α1AT, although they do accumulate α1AT in the liver (Zhang et al., 2011).
aPKC staining was abnormally punctate specifically in the 10% of Dcas1/Dcas1embryos which had discernible GBR defects.
None of the three mutant lines that we isolated had discernible developmental defects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com