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The two-month investigation by the safety agency concluded that "no discernible defect trend exists" and modifications that G.M. already has agreed to make are sufficient to reduce the potential for a fire.
At the completion of its investigation NHTSA concluded that no discernible defect trend exists.
In contrast, mice deficient in LMAN1 do not display any discernible defect in the hepatic intracellular levels of cathepsins Z and C, or plasma levels of α1AT, although they do accumulate α1AT in the liver (Zhang et al., 2011).
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We reasoned, given our earlier observation that Vav1+/−/Vav2−/−/Vav3−/− mice (which express only Vav1 but not Vav2 or Vav3) show no discernible defects in T-lineage cells [29], that reintroduction of Vav1 alone should be sufficient to rescue VavNULL T cell development and function.
Current questions about lead exposure focus on the consequences of levels too low to have erupted into blatantly discernible defects.
In the absence of any discernible defects on hair cell integrity and prompted by the in vitro results, we then analyzed spiral ganglion density and synaptic connections.
Homozygous PSD95SH3W470L mice were fertile, showed normal Mendelian transmission, no obvious seizures, tremor, ataxia or other overt neurological abnormality, nor any discernible defects in gross neuroanatomy as determined histologically (data not shown).
The expression of aPKCCAAXDN in otherwise wild-type clones of tissue produced no discernible defects in cell morphology, proliferation or differentiation during larval stages of development (data not shown).
However, we note that the constitutive Ddit3 knockout mice used in this study did not display any discernible erythroid defect (C.F., unpublished data).
Furthermore, mutant viruses in which ORF1 and ORF2 were deleted demonstrated no discernible growth defect in thymus liver implants, while virus lacking ORF3 grew slightly, but not significantly, slower than the wild-type virus.
However, CNB1 and CRZ1 are known to be required for full virulence of C. glabrata in mice (whereas a rcn1Δ C. glabrata strain does not have a discernible virulence defect) (Chen et al., 2012).
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