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Unlike other species [ 40], no discernable population bottleneck accompanied this shift, suggesting the invaders were easy to exploit as hosts.
However, there was no discernable population of DN3 thymocytes selectively immune reactive with the PKD2 phospho-Ser antisera that could correlate with the subset of DN3 that express the pre-TCR.
Interestingly, microscopy of the population expressing the Orc1-1 WAlker A mutant also shows aberrant large cells (3.8%); however, in agreement with the flow-cytometry profiles, there is not a discernable population of cells with elevated DNA content (as adjudged by DAPI staining).
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It might therefore be anticipated that similar climatic correlations may be discernable in the population structure of cultivated barley.
Genetic deletion of mouse Nat2 has not created an overt phenotype; however, some of these studies in mice indicate that Nat2 deletion gives rise to skewed sex ratios both on mixed [36] and pure [37] genetic backgrounds, indicating a gender-dependent phenotype, discernable at the population level, that is consistent with a role in endocrine function.
Furthermore, since the pathology of these disorders is often only discernable in aged populations, testing the therapeutic value of small molecules in vertebrate disease models requires time consuming and costly experimental designs.
Blood from control and PKCε−/− mice rapidly forms platelet aggregates on collagen, which continue to increase in size over the course of several minutes, with no discernable difference in either population (Fig 7A).
Given that the house mouse niche was created by humans, it has been suggested that demographic changes in humans can lead to similar changes in house mice and that these can leave a discernable trace in the population genetics of both species [ 7].
Substantial changes in the in vivo levels of the studied cell populations were discernable over a period of 16 days following either injection (Figure 2).
As such, within the experimental period generations remained discrete and were discernable by peaks in weekly population counts which, as expected, reached a maximum level once per generation (approximately every 3 weeks; see below).
We recognize that the use of whole ovarian tissue to measure mRNA levels of key genes may have masked any discernable changes specific to follicle populations, had they been processed and examined separately.
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