Sorting out this massive amount of data to discover 'real' somatic mutations and discard the remaining changes (which, besides some 'noise', represent a treasure trove of valuable data, for example of germline genetic variation) was no simple task, both experimentally and computationally.
However, we do not discard the possibility that changes in protein charge, along with other protein characteristics, could explain the different aggregation propensities of ALS mutants.
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Similarly, we discarded the typical changes found at the site of former hair follicles in androgenic alopecia [ 2, 11, 13].
Mr. Potok, a writer and painter who is blind, makes an impassioned plea for empowering the disabled through new tools and laws, and for attitudinal changes that discard the notion that employing the disabled is "a charitable deed".
Twenty-four hours after the fusion, HAT (hypoxanthine-aminopterin-thymidine) was added to the medium and four days later, the whole medium was changed to discard the non-fused cells.
How do we know when to keep old information that is still relevant to the decision, and when to discard the old information because a change might have occurred that renders it irrelevant?
Our analyses allowed us to discard that changes in substitution rates could be correlated with increased mitochondrial genome rearrangement or diversification rates observed in different lineages of neobatrachians.
