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Immunolabelling using antibodies directed to different phosphorylation sites on the Cx43 molecule suggests that dephosphorylated Cx43 is associated with the laterally distributed gap junction label, while those gap junctions that remain in the classic, polar intercalated disc orientation contain phosphorylated Cx43.
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The change in the disc's orientation relative to the condyle moves its load-bearing zone from the biconcave articular portion to the vascularized posterior band, which has been shown to lead to osteoarthritis and subsequent condylar and mandibular deficiencies [25 27].
24 The intervention group will receive basic exercise equipment (ie, resistance bands, yoga mat and exercise logs) and a total of three DVDs: one orientation disc and two discs containing six progressive exercise sessions.
Instead, they attached on both sides to the disc epithelium, adopting orientations perpendicular to the proximal-distal axis.
A flat edge was made on some of the discs to ease orientation and registration during imaging and analysis.
The numerical approach is validated using uniform flow past a stationary circular cylinder, sedimentation of circular discs, and particle motion (orientation and translation) in unidirectional flows.
DOI: http://dx.doi.org/10.7554/eLife.03126.005 Since twin-spot MARCM experiments indicate that a transition from a symmetrical to an asymmetrical mode of cell division occurs between the second and third larval instar stage, we focused on the mitotically active cells in the layer adjacent to the wing disc epithelium and examined the orientation of the axis of division at these two stages.
The thermal analysis of the receiver is carried out for various geometrical parameters such as angle, orientation, height of the disc (H) and distance between the discs (w) and for different heat flux conditions.
Throughout larval wing discs and pupal wings, MT orientation correlates with the direction of Ds and Fj gradients.
Reviewer 1: "The authors state that "Throughout larval wing discs and pupal wings, MT orientation correlates with the direction of Ds and Fj gradients".
DOI: http://dx.doi.org/10.7554/eLife.02893.016 To determine whether Ft-Ds signaling regulates MT orientation in wing discs, and to determine whether it is instructive or merely necessary, we studied the boundaries of ft clones.
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