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Three different surface finishes were obtained by fabricating disc components in the horizontal (0°), inclined (55°) and vertical (90°) in the EBM build chamber.
A variety of materials have been developed to replace disc components, including the nucleus pulposus (NP), the annulus fibrosus (AF) and their combination into disc-like engineered constructs.
Further, we show that Fas recruits the DISC components (FADD and caspase-8).
More importantly, there is strong co-localization of Xin with known intercalated disc components, such as β-catenin, N-cadherin and plakoglobin in the mouse, chicken, frog and fish hearts.
Electron microscopy analyses allowed to visualize the formation of raft clusters and their co-localization with DISC components Fas/CD95, FADD, and procaspase-8 following edelfosine treatment of Jurkat cells.
The presence of multiple gold particles, labeling rafts (Figure 2A 2D) and DISC components (Figure 2B 2D), suggests a high local molecule concentration of DISC constituents in raft platforms, in keeping with the formation of DISC-rich raft clusters.
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The current study analyzes the biodegradation of a polycarbonate polyurethane scaffold intended for the growth of a tissue-engineered annulus fibrosus (AF) disc component.
This paper investigates the mechanisms of facet nucleation through combining aero-engine manufacturer disc component test data with microstructure-sensitive crystal plasticity finite element (CPFE) models.
Even though CENP-F is not a disc component, its loss clearly demonstrates a previously unknown mechanism for dilated cardiomyopathy, "a disease of the intercalated disc" (Perriard et al., 2003).
As observed in MDA-MB-231, disappearance of c-FLIP from the soluble fraction in these cells was always more efficient than depletion of FADD, RIPK1, caspase-8 or caspase-10, suggesting that enough DISC component remains in the cytosol to allow efficient TRAIL-induced cell death in the absence of c-FLIP.
Mutations in genes encoding Z-disc components or their interacting proteins have been identified as being responsible for myofibrillar myopathy development [2], [3].
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Justyna Jupowicz-Kozak
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