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To examine the pattern of myopia-related macular and optic disc changes in Singapore adults with high myopia (spherical equivalent ≤−6.00 diopters).
To assess the correlation between intraocular pressure (IOP) and future optic disc changes in eyes of patients suspected of having high-tension glaucoma and to determine the target pressure in eyes of patients suspected of having high-tension glaucoma.
With increasing age and degeneration the disc changes in morphology, becoming more and more disorganized (Fig. 2).
Eligible patients were aged 25-55 and had low back pain as the main symptom for at least a year, structured physiotherapy or chiropractic treatment for at least six months without sufficient effect, a score of at least 30 on the Oswestry disability index, and degenerative intervertebral disc changes in L4/L5 or L5/S1, or both.
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To investigate the rate of visual field and optic disc change in patients with distinct patterns of glaucomatous optic disc damage.
While both T2 and MTR identified degenerative changes in the discs, change in T2 was more sensitive to the differences in disc status, especially for the CEPZ.
To determine the agreement among glaucoma specialists in assessing progressive disc changes from photographs in a cohort of patients with glaucomatous visual field loss.
Animals were included in the study before reaching adulthood in order to take into account the impact of growth in intervertebral disc changes, and were kept in a safe laboratory environment with stable humidity, temperature of 21°C and artificial daylight for 12 hours.
TNFα is elevated in the degenerating disc, induces changes in the biochemical features of discs, notably a loss in proteogycans, stimulates production of nerve growth factor [ 29], and has been found to regulate MMP3 in nucleus pulposus cells [ 30].
Glaucomatous optic disc changes may confound the relationship between BRVO and ONH parameters, therefore criteria for inclusion were: intraocular pressure <22 mmHg, no evidence of glaucomatous changes in optic disc or no history of POAG or anti-glaucoma treatment and no history of POAG in first-degree relatives.
To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com