These results provide structural evidence that disarray at the molecular level may be linked to the histopathological myocyte disarray characteristic of the diseased state.
The possibility exists that the structural differences observed here may be isoform-specific; however, we favor the view that the morphological disarray characteristic of cardiac myosin R403Q-caused FHC, is a direct outcome of molecular level conformational variability in the actomyosin modes of interactions.
Collectively, these findings likely represent regional myocardial disarray and replacement fibrosis, characteristic of HCM that lead to non-uniformity of morphology, contractile function and altered intramural deformational mechanics.
Zebrafish homozygous for a null tnnt2 mutation (silent heart), with severe truncation of Tnnt2 protein or lack of translation, develop ultrastructural characteristics of HCM, mainly sarcomeric disarray.
Hearts of the tr265/tr265 Danio rerio mutant become larger than those of the sibling by week 4 post fertilization and gradually exhibit characteristics of human cardiomyopathy, such as muscular disarray, re-activated fetal gene expression, and severe arrhythmia.
Australia had rebounded from the chaos and disarray of the final months of the Mickey Arthur regime, whose defining characteristic was the ability to consistently forge defeat in the face of multiple PowerPoint presentations.
Here, we observed ultrastructural characteristics of tw mutant flies and discovered various phenotypes: sarcomeric disarray, irregular Z-lines, filament disorganization, swollen SR, accumulation of glycogen granules, enlargement of mitochondria, and duplication of basement membranes (Figs. 4 and 5).
While confusion and disarray reign within the circles of power in Washington, clarity seems to be the defining characteristic of the Islamic State.
The new pope's austerity extends to his professional life, a characteristic that could help him put some order in a Vatican that by all accounts is in disarray, especially financially.
Voter registration is in disarray.
The Democrats are in disarray.
