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GlaxoSmithKline lost 13p to 1637.5p after a disappointing trial result for an experimental heart drug.
AstraZeneca fell 54p to £32.80 on disappointing trial results for its experimental prostate cancer pill zibotentan.
The companies' shares plummeted after they announced the disappointing trial results, and SAC booked big profits.
But another big faller is AstraZeneca after a disappointing trial result for its cholesterol drug Crestor, its biggest selling product.
Two days later, Genentech and Xoma announced the disappointing trial results, and Xoma's stock dropped 42percentt.
As leading shares ended the quarter on an upbeat note, Shire was an exception after the drugs group reported a disappointing trial result.
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You've experienced promising starts and a succession of disappointing trials.
Doctors and politicians want more transparency, meaning no sweeping of disappointing trials under rugs.
Although clinical results from TOR complex 1 (TORC1 -specific inhibiTORC1 -specificmycinhibition have been disappointing, trials using inhibitorapamycinlso tanalogsORC2 have been promising.
Elsewhere GlaxoSmithkline lost 26.5p to 1591.5p after disappointing drug trial results.
One disappointing drug trial caused the company's stock to plunge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com