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I would not be surprised if some such drugs would exhibit disappointing levels of inhibitory activity, so that mutational escape would not be essential for the virus to continue to replicate.
However, in light of disappointing levels of efficacy reported in the target infant age group in the interim analysis of the Phase III trial of the leading pre-erythrocytic vaccine RTS,S, and in the continued absence of any highly effective malaria vaccine targeting any stage of the parasite lifecycle, it remains vital that the merits of all promising new approaches are assessed.
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The questionnaire revealed a disappointing level of knowledge about BLS in both groups.
The questionnaire revealed a disappointing level of knowledge of the fundamentals of BLS in both groups.
Stripping off the gains from stocks and other investments, Deutsche Bank believe Ping Ans full-year profit growth rate will fall to a very disappointing level of 12% to 13%.
Originally scheduled to start in June, the race was postponed one month, and the prize money was increased, after a disappointing level of applications from competitors.
It is somewhat disappointing that levels of other marker molecules, such as various cytokines, cytokine receptors or matrix metalloproteinases, have not been shown to exhibit better correlations with actual disease manifestations or outcomes of RA than acute phase reactants.
Gene transfer trials for heart disease have thus far been disappointing perhaps because of inadequate levels of gene expression in the heart.
76, 85, 86 Intriguingly, in the rhMOG/CFA model indirect peripheral B-cell depletion via treatment with fully human mAbs against two major stimulatory factors of B-cell development and survival, BLyS/BAFF (belimumab) or APRIL, exerted a disappointing clinical effect although serum levels of anti-MOG antibodies were reduced.
Considering the Australian Government Teen Dental Program aimed at low socio-economic families had an emphasis on preventive care [ 23], it is disappointing to note the low levels of topical fluoride use and oral hygiene instruction across LHDs, as these are relatively simple and quick procedures that assist in dental caries prevention [ 9].
It was disappointing that the level of knowledge related to 'HIV/AIDS' and 'respect for girls' did not change substantially in any of the groups following the intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com