Sentence examples for disappointing efficacy from inspiring English sources

Farnesyl transferase inhibitors, which inhibit Ras function by preventing its translocation to the plasma membrane, have shown disappointing efficacy in clinical trials [24].

When the favorable safety and disappointing efficacy results were available from the groups described above, higher doses of vaccines were used in phase three, in two further non-randomized study groups (I, J).

Platinum-free regimens exhibited disappointing efficacy in randomised trials.

Unfortunately, since its disappointing efficacy before, chemotherapy was not recommended after the diagnosis of ICC for patients in this study.

Similar disappointing efficacy results were obtained in clinical trials of XR9576 (tariquidar) and docetaxel, and at present, there are no plans for further clinical development (www.qltinc.com).

Factors explaining the disappointing efficacy of ravuconazole and posaconazole in humans may include the folowing: (1) Intracellular localization of T. cruzi parasites in chronic infection, largely in heart, gut, and skeletal muscles, requires drugs with different pharmacokinetic profiles.

Therapeutic options currently available are limited, and often disappointing in efficacy.

Because of prohibitive dermatological toxicity and disappointing preliminary efficacy, this combination of paclitaxel/cetuximab was not considered promising.

The clinical outcome of the LM/TMZ combination was disappointing, with efficacy similar to that of standard dose TMZ (Ranson et al, 2007).

One systematic analysis revealed a disappointing 59% efficacy in preventing confirmed influenza and 36% effectiveness in preventing influenza-like illness in children aged below 2 y but efficacy similar to that of placebo in younger (immunologically unprimed) children.

However, in light of disappointing levels of efficacy reported in the target infant age group in the interim analysis of the Phase III trial of the leading pre-erythrocytic vaccine RTS,S, and in the continued absence of any highly effective malaria vaccine targeting any stage of the parasite lifecycle, it remains vital that the merits of all promising new approaches are assessed.