Continuing medical education and continuing professional development have been the traditional modalities for implementing changes in clinical practice, but their effectiveness has been disappointing.
Indeed, several experiments using machine learning to improve information retrieval were disappointing or at least inconclusive considering effectiveness (30) and efficiency (31).
"They have been for 10 years, and the effectiveness of that has been disappointing".
However, the clinical effectiveness of these agents have been disappointing because of cooperation between different ErbB family members that can rescue cancer cells from agents directed against a single ErbB receptor subtype.
Recent research data from some GABAergic compounds, including gabapentin [ 93, 94], tiagabine [ 95], topiramate [ 96], have produced disappointing and conflicting results as far as their effectiveness in bipolar disorder is concerned.
One systematic analysis revealed a disappointing 59% efficacy in preventing confirmed influenza and 36% effectiveness in preventing influenza-like illness in children aged below 2 y but efficacy similar to that of placebo in younger (immunologically unprimed) children.
Critiques have highlighted concerns that the evidence-base of its effectiveness is limited, with controlled trials reporting disappointing results, and its prescription promotes 'performance-based' sexuality which may be detrimental.
The results from MMP inhibitors in human trials are so far disappointing because these inhibitors suffer from a range of side effects and show little effectiveness in preventing joint destruction.
The federal government sponsored extensive research into the effectiveness of both, but the findings were painfully disappointing.
It's beyond disappointing that the Treasury plan offers no way to measure regulators' effectiveness or hold them accountable for their failures.
