Sentence examples for disaggregation activity from inspiring English sources
The high refolding or disaggregation activity of neurons was supported by visualization of Luc GFP inclusions and analysis of aggregates by immunoblotting (Figures 2B, C).
Therefore, N-terminal contributions to prion disaggregation activity might explain why the Sc_Hsp104/CTDSp chimera cures [PSI+] despite bearing the CTD from Sp_Hsp104.
Next, we tested the disaggregation activity of the arginine mutants.
The C-terminal tagging does not hamper Hsp104 disaggregation activity (Specht et al., 2011 ).
Indeed, mutations of the conserved tyrosine residue on helix L3 abolish disaggregation activity in ClpB (Haslberger et al., 2007).
This indicates that maintenance of the liquid-like P-body state requires the continuous action of Hsp104 during acute stress and that P-body components are mistargeted to stress granules, when the disaggregation activity is insufficient.
Although we are beginning to understand how propagon generation is achieved through the molecular chaperone and protein disaggregation activities of Hsp104 [30] [32], the molecular composition of the 'infectious' propagon remains elusive.
ClpB disaggregation activities were determined by following the refolding of aggregated firefly Luciferase according to published protocols (Haslberger et al., 2007).
Among the entire series compounds IP-9, IP-13 and IP-15 appeared as most active multi-functional agents and displayed marked AChE inhibitory, Aβ disaggregation and antioxidant activity.
In summary, mutation of any of the conserved arginines in the coiled coil results in severe effects on ATPase activity, prion disaggregation and thermotolerance, which can be explained when the coiled-coil domain is intercalated between NBD1 and NBD2.
Disaggregation and dispersion of activities is though a double edged sword as it simultaneously enhances the access to resources and talent increasing the value of knowledge development activities in the firm, but also add to the costs of management and coordination.
