Sentence examples for disadvantages of blocking from inspiring English sources

Although there is an ongoing debate on the advantages and disadvantages of blocking ETB receptors in patients, there does not appear to be a major difference in clinical efficacy in treating patients with pulmonary arterial hypertension between selective ETA receptor antagonists and dual ETA and ETB receptor antagonists [ 20, 21].

Natural, daytime sunlight is better at giving you serotonin than artificial LED, fluorescent, or UV light.[9] Getting artificial light, especially at night, has the added disadvantage of blocking melatonin production, which helps your body get a good night's sleep.

The major disadvantages to blocking the kinase activity of PLK-1 are that ATP-competitive inhibitors commonly inhibit all PLK paralogs, including PLK-3 (tumor suppressor), and a single point mutation in the catalytic site of PLK-1 (S67V) results in dramatic resistance to the structurally diverse ATP-competitive inhibitors [ 54].

In the right-wing litany, trade unions stand accused of causing unemployment by inflating wages, of generating inequality by disadvantaging the non-unionized, and of blocking productivity growth and investment by defending outmoded working practices and staffing levels.

Moreover, a block adjustment algorithm is developed using the indicator to overcome the main disadvantage of block-induced algorithms, i.e., the dependency on cluster location.

The engine allows this while bypassing the disadvantages of big-block engines: excessive weight, which compromised handling; big, bulging hoods, which hampered visibility; and voracious fuel consumption.

For detailed, comprehensive discussions of the advantages and disadvantages of translation-blocking versus splice-site targeting MOs, see [ 3, 4].

The simplicity of these techniques is one of the advantages of airway blocks [ 3] but complications such as elimination of highly effective airway protective reflexes, bleeding, nerve damage and intravascular injection are the disadvantages of airway blocks [ 2].

Since the objective function is linear and the constraint functions are polynomials of no more than degree-2, it is weak in nonlinearity and can be solved by those conventional optimization techniques, and disadvantages of the conventional block theory are overcome.

But water retention is the main disadvantage of this block, because thermal insulation properties are severely compromised.

The increasing cost and frequent unavailability within economic distance of suitable natural rock has provoked considerable thought to the design of concrete armour units that can, by reason of their shape, overcome the disadvantages of the simple cubic, or rectangular, block.