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The research may eventually help doctors reduce disabling side effects of glucocorticoid drugs such as prednisone, Feldmansaid.
Worse yet, some patients suffered serious, disabling side effects, including severe bleeding, stroke or heart problems, severe high blood pressure and development of holes in the gastrointestinal tract.
During chemotherapy, patients experience disabling side effects or even sometimes life-threatening treatment-related complications, contributing to poor quality of life, reduced therapeutic compliance, decreased relative dose-intensity, and ultimately poorer outcomes.
Yet the notion that denying an illness is proof of its existence is a dangerous one, since there are many valid reasons that people choose to refuse treatment, including the stigma of having a mental illness and the disabling side effects of medication.
Some feel that the benefits far outweigh the risks, especially considering that many FDA-approved antiepileptic drugs have disabling side effects—especially when used at high doses in combination.
After excluding the patient with disabling side effects, we included a total of 14 patients with refractory CLE.
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Frequently, disabling side-effects in particular dyskinesias occur [4].
One patient discontinued the study after 1 week due to disabling gastrointestinal side effects (patient number 3).
l-dopa-induced dyskinesias (LIDs) are the most disabling side-effects of pharmacological treatment in patients with Parkinson's disease (Fahn, 2003).
Disabling side-effects of steroid treatment, including cataract formation, glaucoma, osteoporosis, Cushing's syndrome or diabetes mellitus, and the refractory character of the uveitis in some sarcoidosis patients, stress the need for alternatives.
However, in case this treatment does not have a favorable outcome or if disabling side-effects, which accompany prolonged treatment occur, use of other alternative, steroid-sparing agents is mandatory.
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