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Purpose and hypothesis: Patellar ligament rupture is a rare disabling pathology requiring a surgical ligament suture protected by a frame.
Ankle osteoarthritis (AOA) is a severe disabling pathology affecting 1%% of the adult population (Barg et al. 2013; Valderrabano et al. 2009).
A prospective study was carried out with 77 consecutive hospital inpatients of geriatric age in a medium- and long-term unit (from La Fe Hospital in Valencia, Spain) admitted for decompensated chronic pathology or acute disabling pathology with loss of walking ability.
Better education and awareness about such a prevalent and disabling pathology and its management should be favored.
The major demyelinating disease of the CNS is multiple sclerosis, which is the foremost disabling pathology among young adults.
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They were not included if they had chronic loss of autonomy (a KATZ score below 6/6 [13], a degenerative neurological pathology with disabling muscle weakness, were agitated prior to the evaluation (Ramsay score of 1 or Richmond Agitation-Sedation Scale (RASS) greater than 1) or a decision to withhold life sustaining treatment had been made.
Thus, the mouse experiments indicate that an immunomodulatory treatment that dampens the inflammatory immune response, while not disabling it, may help curbing flaviviral CNS pathology.
The antibody was able to significantly reduce early and late tau pathology, showing that DC8E8 targets and disables disease-modified mis-disordered tau.
Over the course of Alzheimer's disease (AD), neurofibrillary pathology spreads through the human brain, gradually disabling affected regions and leading to a decline in cognitive function.
We identified such a common denominator, a domain on mis-disordered truncated tau that is essential for propagation of tau pathology, and we created a monoclonal antibody DC8E8 that disables this function.
More like cultural pathology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com