Neither eligible patients with a Kellgren & Lawrence (K-L) score of 4 [ 11], nor people with renal and/or hepatic disease, diabetes mellitus or a disabling co-morbidity are included.
Future studies investigating the effect of human, non-activated PC concentrate should focus on the potential benefit of early PC therapy in PF, and amputations and skin grafts as important outcome measures in this condition, which, despite recent advances in mortality control, still carries a high risk of disabling long-term morbidity.
Characteristics evaluated included age, pregnancy status, sex, respiratory signs and symptoms, smoking and alcohol history, CURB-65 score, co-morbidities, disabling sequelae, length of stay and in-hospital mortality outcomes.
Psychotic depression (PD) is a severe disabling disorder with considerable morbidity and mortality.
Neuromyelitis optica (NMO) is a rare antibody-mediated CNS disease characterised by disabling relapses leading to high morbidity and mortality.
DM is associated with serious morbidity and chronic disabling complications attributing to its high rate of mortality.
We subtracted utilities associated with temporary states in our model, such as deep vein thrombosis, from the baseline utility, but we considered events having long-term morbidity, such as disabling neurological deficit, by multiplying the associated utility by the baseline utility [ 28].
In order to avoid disabling morbidity associated with axillary dissection such as lymphoedema, a successful SLNB is of great importance.
Bipolar disorder (BD) is a prevalent, chronic, severe, and highly disabling psychiatric disorder that is associated with increased morbidity and mortality due to general medical conditions.
Diabetes (type 1 and type 2) is a chronic disabling condition that is a major cause of morbidity and mortality, and is thought to affect around 3.38 million people within the UK in 2014 [ 7].
Inguinal nodes dissection is associated with high rates of morbidity, lymphedema in particular is a chronic disabling condition which is a common complication following this operation.
