Sentence examples for disabled mutant from inspiring English sources

This wt chimeric construct showed impressive (>80%) protection against, virus challenge, on the other hand, the selectively disabled mutant constructs were less effective.

This conclusion is strongly supported by the fact that the HS-binding disabled mutant γ-m2 is devoid of detectable activity in vivo despite it shows full agonist potency on CXCR4 in vitro.

Similarly, in several instances agonist-induced internalization of a given GPCR has been shown to promote internalization of either a disabled mutant or a different GPCR altogether [7], [8], [9], [10], [11].

Why do textbooks use fruit flies with an extra pair of wings as evidence that DNA mutations can supply raw materials for evolution — even though the extra wings have no muscles and these disabled mutants cannot survive outside the laboratory?

Award-winning Spanish director Alex de la Iglesia used music by the band in his 1993 black comedy film Acción mutante (Mutant Action) about a terrorist group made up of disabled people.

Overexpression of IncA in HEK293 cells caused the same effect, whereas an IncA mutant disabled to interact with G3BP1 in yeast did not cause a decrease in c-Myc protein concentration.

This effect could be ascribed to the interaction between IncA and G3BP1 since overexpression of an IncA mutant construct disabled to interact with G3BP1 failed to reduce c-Myc concentration.

However, these mutants are disabled in complex formation (Van Humbeeck et al, 2008), and do not localize to mitochondria (Matsuda et al, 2010), suggesting that they are functionally impaired.

To ensure that effect of the R1039A mutation is indeed measured in trans, we additionally disabled the catalytic site of the R1039A mutant by the H1061N mutation, as outlined in Figure 4a.

– Severe Disability: (Conscious but disabled).

All three mutants were responsive to SAG, showing that they were not disabled, but demonstrated substantially reduced 20(S -OHC binding and reS -OHCveness, with the mSmo Y134F bindingompletely unresponsive.