Sentence examples for disable expression from inspiring English sources

The use of small interfering RNAs (siRNAs) to disable expression of survival genes provides a tool for killing these cancer cells.

To disable prokaryotic expression from the CMV promoter a series of genetic manipulations were performed to remove the two major bacterial promoters and add a bacteria transcription terminator downstream of the CMV promoter.

With a catalytically active Cas9 protein, the CRISPR approach can generate gene disruption, whereas a defective Cas9 (dcan9) can either enable or disable the expression of a defined gene.

Indeed, as expected, disabling the expression of TrkB completely blocked the RA-induced neurite outgrowth in SH-SY5Y (Figure 3D) and LAN-5 (Figure 3G) cells but had no effect on SK-N-BE cells morphology (Figure 3J).

Taken together, the results demonstrate that disabling the expression of either Ret or TrkB causes a failure in RA-dependent cell differentiation, thus raising the question of the existence of a cooperative cross-talk between TrkB and Ret in neuroblastoma cells.

pcDNA-LT136, encoding LT136 only, was constructed by introducing an intron deletion disabling ST expression.

Alternatively, a mutation may have disabled the expression of call differences either before or after the colonization.

Its expression disables germinal center formation by binding to and thus repressing BCL6 [30] [33].

Studies of a dimer interface mutant support the conclusion that persistent cytosolic expression disables mature Smac dimerization.

The 25(OH D3-DBP complex is internalized via receptor-mediated endocytosis, which is absolutely dependent on the membrane receptors megalin (LPR2), cubilin (CUBN) and the adaptor protein disabled-2 (DAB2), the expression of these proteins is in turn modulated by retinoids [ 89].

Deletion and amplification in these CNVs may just prohibit the gene's expression or disable the gene's function with aberrant isoforms.